Methyl 1-(tert-butoxycarbonyl)-3-piperidinedicarboxylate
Methyl N-Boc-piperidine-3-carboxylate
CAS: 148763-41-1
Molecular Formula: C12H21NO4
Methyl 1-(tert-butoxycarbonyl)-3-piperidinedicarboxylate - Names and Identifiers
Methyl 1-(tert-butoxycarbonyl)-3-piperidinedicarboxylate - Physico-chemical Properties
| Molecular Formula | C12H21NO4 |
| Molar Mass | 243.3 |
| Density | 1.094±0.06 g/cm3(Predicted) |
| Melting Point | 47.0 to 51.0 °C |
| Boling Point | 307.4±35.0 °C(Predicted) |
| Flash Point | 139.7°C |
| Vapor Presure | 0.000726mmHg at 25°C |
| Appearance | powder to crystal |
| Color | White to Light yellow |
| pKa | -2.48±0.40(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | 1.473 |
| MDL | MFCD06795926 |
Methyl 1-(tert-butoxycarbonyl)-3-piperidinedicarboxylate - Risk and Safety
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| HS Code | 29333990 |
Methyl 1-(tert-butoxycarbonyl)-3-piperidinedicarboxylate - Introduction
Methyl N-Boc-piperidine-3-carboxylate is an organic compound with the chemical formula C11H19NO3. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: Methyl N-Boc-piperidine-3-carboxylate is a colorless to pale yellow liquid.
-Odor: Has a special smell.
-Solubility: Soluble in organic solvents such as dimethylformamide (DMF) and acetonitrile.
Use:
- Methyl N-Boc-piperidine-3-carboxylate is a commonly used organic synthesis intermediates, often used in drug synthesis.
-It can be used as a deprotection reagent for carbonyl compounds and amine compounds, and can be used to synthesize biologically active compounds.
Method:
The preparation method of Methyl N-Boc-piperidine-3-carboxylate is more complicated, and a common synthetic route is as follows:
1. First, dissolve methyl 3-piperidinecarboxylate in dimethylformamide.
2. Then, add Boc protecting reagent and corresponding base catalyst.
3. The reaction is carried out at an appropriate temperature and reaction time.
4. After the reaction, the reaction mixture can be treated by adding acid and extracting to obtain the target product.
Safety Information:
- Methyl N-Boc-piperidine-3-carboxylate may be irritating to the eyes, skin and respiratory tract. If you come into contact with this substance, rinse the affected area with plenty of water in time.
-Wear personal protective equipment such as chemical protective gloves, goggles and masks when using and handling the substance.
-should be operated in a well-ventilated place to avoid inhalation of its vapors.
-Please follow the relevant safety procedures and disposal methods to ensure the safe use of the compound.
Nature:
-Appearance: Methyl N-Boc-piperidine-3-carboxylate is a colorless to pale yellow liquid.
-Odor: Has a special smell.
-Solubility: Soluble in organic solvents such as dimethylformamide (DMF) and acetonitrile.
Use:
- Methyl N-Boc-piperidine-3-carboxylate is a commonly used organic synthesis intermediates, often used in drug synthesis.
-It can be used as a deprotection reagent for carbonyl compounds and amine compounds, and can be used to synthesize biologically active compounds.
Method:
The preparation method of Methyl N-Boc-piperidine-3-carboxylate is more complicated, and a common synthetic route is as follows:
1. First, dissolve methyl 3-piperidinecarboxylate in dimethylformamide.
2. Then, add Boc protecting reagent and corresponding base catalyst.
3. The reaction is carried out at an appropriate temperature and reaction time.
4. After the reaction, the reaction mixture can be treated by adding acid and extracting to obtain the target product.
Safety Information:
- Methyl N-Boc-piperidine-3-carboxylate may be irritating to the eyes, skin and respiratory tract. If you come into contact with this substance, rinse the affected area with plenty of water in time.
-Wear personal protective equipment such as chemical protective gloves, goggles and masks when using and handling the substance.
-should be operated in a well-ventilated place to avoid inhalation of its vapors.
-Please follow the relevant safety procedures and disposal methods to ensure the safe use of the compound.
Last Update：2024-04-09 21:01:54
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Product Name: N-Boc-nipecotic acid methyl ester Visit Supplier Webpage Request for quotation
CAS: 148763-41-1
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Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 148763-41-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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